​Who we are:

NeuCyte is an early-stage biotechnology company that focuses on developing human stem cell-based models for neurological and neurodegenerative disorders. These models can be used to develop translatable cell-based assays using patient-derived and genetically engineered neural cell types to identify more translatable novel therapeutics. Based on our SynFire® technology, our proprietary human neural in vitro platforms assess complex electrophysiological and morphological readouts suited for target identification and validation, as well as drug efficacy testing. ​

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What we're looking for: 

NeuCyte is seeking a highly motivated independent Scientist II to join our stem cell technology team. In this role, the successful candidate will apply their expertise in iPSC-derived cells and disease modeling to develop human stem cell-based in vitro models of neurodegenerative diseases. The candidate will employ these models for phenotypic assay development for drug discovery screening efforts. This position requires a strong background in iPSC cell culture, disease modeling, and phenotypic assay development. 

What you’ll do:

• Differentiate patient iPSC lines into neural cell types. 

• Perform gene-editing of iPSCs to correct mutations or introduce disease modeling mutations. 

• Develop novel iPSC-derived 2D & 3D models for central nervous system (CNS) diseases to identify phenotypes for drug discovery/screening. 

• Participate in/lead the design and implementation of manufacturing scale up of existing or new iPSC-derived cell types. 

• Participate in the design and implementation of QA and QC assay criteria. 

• Participate in/lead the design and implementation of cell-based assays that includes high-content imaging for phenotypic drug screening using both high-throughput and live cell imaging platforms, and development of automated image analysis pipelines. 

• Keep up with the technology of the field, review relevant literature, and evaluate systems and analysis solutions. 

• Prepare SOPs and train/supervise technical staff to assist with assays as needed. 

• Write project reports and present projects at internal and external meetings. 

• Work together with the team

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Required: 

• PhD with 3-5 years of iPSC experience, preferably in fast-paced lab environment, with a strong neuroscience background. 

• Hands-on experience with iPSC culturing and multi-lineage differentiation of CNS cell types i.e., different neuronal cell types, astrocytes, microglia, or brain microvascular endothelial cells. 

• Previous neurodegenerative disease modeling including co-culture in 2D and 3D using complex systems such as brain assembloids/organoids. 

• Experience with phenotypic assay development and data interpretation. 

• Proficiency in the use of high-content imaging systems and related data analysis software. 

• Basic genomics knowledge. 

• Able to multi-task and participate/lead multiple projects simultaneously. 

• Clear written and oral communication and detailed documentation skills. 

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Preferred:

• Experience in industry 

• Experience with high-throughput drug screening. 

• Experience with microfluidics. 

• Experience with omics datasets and bioinformatics. 

• Experience with human iPSC-derived neuron electrophysiology. 

• Experience with molecular biology and biochemistry assays such as DNA and RNA extraction, PCR and qPCR, plasmid construction, Western blotting, ELISA, etc. 

• Basic computer programming skills for data processing. 

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Compensation:

•  Competitive salary and benefits commensurate with experience

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NeuCyte is proud to be an Equal Opportunity Employer and is committed to providing an environment of mutual respect and celebrating diversity.

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Contact info: careers@neucyte.com