Who we are:
NeuCyte is an early stage biotechnology company that focuses on developing treatments for those suffering from neurological and neurodegenerative disorders. We develop translatable cell-based assays for modeling neuro-related disorders using patient-derived and genetically engineered neural cell types to discover novel therapeutics. Based on our SynFire® technology, our proprietary human neural in vitro platforms assess complex electrophysiological and morphological readouts suited for target identification and validation, as well as drug efficacy testing.
What we're looking for:
NeuCyte is seeking a highly motivated Scientist / Senior Scientist to join our team. In this role, the successful candidate will apply their expertise in iPSC-derived disease modeling to develop human stem cell-based in vitro models of neurodegenerative diseases. The candidate will employ these models for phenotypic assay development and drug screening efforts for drug discovery. This position requires a strong background in iPSC cell culture, disease modeling, and phenotypic assay development.
What you’ll do:
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Maintenance of patient iPSC and neuronal cell cultures for molecular biology experiments, high-content imaging, and functional assays
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Participate in/Lead the design and implementation of cell-based assays
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Develop iPSC-derived disease models (2D & 3D) for phenotype extraction and drug discovery/screening for NeuCyte disease programs
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Perform high-content imaging for phenotypic drug screening using both high-throughput and live cell imaging platforms; develop automated image analysis pipelines; support the general needs around imaging and microscopy
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Participate in the design and implementation of QA and QC assay criteria
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Keep up with the technology of the field, review relevant literature, and evaluate systems and analysis solutions
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Prepare SOPs and train/supervise technical staff to assist with assays as needed
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Write project reports, present projects at internal and external meetings
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Work together with the team to maintain instruments, interact with service partners and instrument manufacturers
Required:
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PhD with 3-5 years of iPSC experience, preferably in fast-paced lab environment, with a strong neuroscience background
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Hands-on experience with iPSC culturing and multi-lineage differentiation of CNS cell types i.e., neurons, astrocytes, microglia, or brain microvascular endothelial cells
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Previous neurodegenerative disease modeling (ALS, FTD, Parkinson’s Disease, or Alzheimer’s Disease) including co-culture in 2D and 3D using complex systems such as brain assembloids/organoids
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Experience with phenotypic assay development and data interpretation
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Proficiency in the use of high-content imaging systems and related data analysis software
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Basic genomics knowledge
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Ability to multi-task and participate/lead multiple projects simultaneously
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Clear written and oral communication and detailed documentation skills
Preferred:
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Experience in high-throughput drug screening
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Experience with microfluidics
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Experience with bioinformatics analysis
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Experience with human iPSC-derived neuron electrophysiology
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Experience with molecular biology and biochemistry assays such as DNA and RNA extraction, PCR and qPCR, plasmid construction, Western blotting, ELISA, etc.
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Basic computer programming skills for data processing
Compensation:
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Competitive salary and benefits commensurate with experience
NeuCyte is proud to be an Equal Opportunity Employer and is committed to providing an environment of mutual respect and celebrating diversity.
Contact info: careers@neucyte.com