Relevant Publications
2023
Suzuki, I., et. al. Verification of the seizure liability of compounds based on their in vitrofunctional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivoextrapolation to cerebrospinal fluid concentration. Toxicol Appl Pharmacol., 2023
Bartmann, K., et. al. A Human iPSC-based In VitroNeuralNetwork Formation Assay to Investigate Neurodevelopmental Toxicity of Pesticides. ALTEX, 2023
2022
Ishibashi, Y., et al, Responses to antibiotics in human iPSC-derived neurons based on the clinical antibiotic associated encephalopathy classification. J. Toxicol. Sci., 2022
Pediaditakis, I., et al., A Microengineered Brain-Chip to Model Neuroinflammation in Humans. iSCIENCE, 2022
TCW, J., et. al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell, 2022
Zaer, H., et. al. Non-Ablative Doses of Focal Ionizing Radiation Alters Function of Central Neural Circuits. Brain Stimulation, 2022
2021
Saavedra, L., et. al. Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures. Toxicol Sci., 2021
2020
Tukker, A., et. al. Towards Animal-Free Neurotoxicity Screening: Applicability of hiPSC-Derived Neuronal Models for In Vitro Seizure Liability Assessment. ALTEX, 2020
Soscia, D., et al. A flexible 3-dementional micro electrode array for in vitro brain models. Lab Chip, 2020
2017
Yang, N., et al. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods, 2017
2016
Yi, F., et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science, 2016
2015
Pak, C., et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell, 2015
2013
Zhang, Y., et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron, 2013
Application Note
Long-term functional characterization of SynFire® iNs and astrocytes co-cultured on MaxTwo Multi-Well High-Density Microelectrode Arrays
