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Relevant Publications




Suzuki, I., et. al. Verification of the seizure liability of compounds based on their in vitrofunctional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivoextrapolation to cerebrospinal fluid concentration. Toxicol Appl Pharmacol., 2023



Bartmann, K., et. al. A Human iPSC-based In VitroNeuralNetwork Formation Assay to Investigate Neurodevelopmental Toxicity of Pesticides. ALTEX, 2023




Ishibashi, Y., et al, Responses to antibiotics in human iPSC-derived neurons based on the clinical antibiotic associated encephalopathy classification. J. Toxicol. Sci., 2022 


Pediaditakis, I., et al., A Microengineered Brain-Chip to Model Neuroinflammation in Humans. iSCIENCE, 2022


TCW, J., et. al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell, 2022

Zaer, H., et. al. Non-Ablative Doses of Focal Ionizing Radiation Alters Function of Central Neural Circuits. Brain Stimulation, 2022


Saavedra, L., et. al. Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures. Toxicol Sci., 2021


Tukker, A., et. al. Towards Animal-Free Neurotoxicity Screening: Applicability of hiPSC-Derived Neuronal Models for In Vitro Seizure Liability Assessment. ALTEX, 2020


Soscia, D., et al. A flexible 3-dementional micro electrode array for in vitro brain models. Lab Chip, 2020



Yang, N., et al. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods, 2017



Yi, F., et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science, 2016



Pak, C., et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell, 2015



Zhang, Y., et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron, 2013

Capability Overview
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Application Note

Long-term functional characterization of SynFire® iNs and astrocytes co-cultured on MaxTwo Multi-Well High-Density Microelectrode Arrays

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