Publications and More | NeuCyte, Inc.

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Director, Head of Neuroscience

NeuCyte, Inc. – San Carlos, CA

Contact info: careers@neucyte.com

Application Note

Long-term functional characterization of SynFire® iNs and astrocytes co-cultured on MaxTwo Multi-Well High-Density Microelectrode Arrays

Application Note

Long-term functional characterization of SynFire® iNs and astrocytes co-cultured on MaxTwo Multi-Well High-Density Microelectrode Arrays

Suzuki, I., et. al. Evaluation of neurotoxicity for pesticide-related compounds in human iPS cell-derived neurons using microelectrode array. Toxicology In Vitro, 2023

Relevant Publications

2025

Goshi, N., et. al. Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures. Front. Cell. Neurosci., 2025

2024

Bogguri, C., et. al. Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent. Front. Cell. Neurosci., 2024

Chim, S M., et. al. A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood–Brain Barrier Crossing Therapeutic Strategies. Pharmaceutics., 2024

2023

Lam, D., et. al. Spatiotemporal analysis of 3D human iPSC-derived neural networks using a 3D multi-electrode array. Front. Cell. Neurosci., 2023

Ishibashi, Y., et. al. Evaluation of neurotoxicity for pesticide-related compounds in human iPS cell-derived neurons using microelectrode array. Toxicol In Vitro, 2023

Ishibashi, Y., et. al. Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration. Toxicol Appl Pharmacol., 2023

Bartmann, K., et. al. A Human iPSC-based In Vitro Neural Network Formation Assay to Investigate Neurodevelopmental Toxicity of Pesticides. ALTEX, 2023

2022

Ishibashi, Y., et al, Responses to antibiotics in human iPSC-derived neurons based on the clinical antibiotic associated encephalopathy classification. J. Toxicol. Sci., 2022

Pediaditakis, I., et al., A microengineered Brain-Chip to model neuroinflammation in humans. iScience, 2022

TCW, J., et. al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell, 2022

Zaer, H., et. al. Non-ablative doses of focal ionizing radiation alters function of central neural circuits. Brain Stimulation, 2022

2021

Saavedra, L., et. al. Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures. Toxicol Sci., 2021

2020

Tukker, A., et. al. Towards Animal-Free Neurotoxicity Screening: Applicability of hiPSC-Derived Neuronal Models for In Vitro Seizure Liability Assessment. ALTEX, 2020

Soscia, D., et al. A flexible 3-dimensional microelectrode array for in vitro brain models. Lab Chip, 2020

2017

Yang, N., et al. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods, 2017

2016

Yi, F., et al. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science, 2016

2015

Pak, C., et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell, 2015

2013

Zhang, Y., et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron, 2013

Webinars

Establishing an In Vitro Assay for Effectively Predicting Neurotoxicity Risks Using Functional Human iPSC-Derived Neurons

Building Effective Stem Cell-Based Models of Brain Disorders for Drug Discovery & Therapeutic Development

Building Confidence in Neurotoxicity Testing Using an In Vitro Phenotypic Assay Platform Based on Human iPSC-Derived Neurons

Beyond iPSC Based Disease Models- A Translatable Drug Discovery Platform for Status Epilepticus

Assessing the Suitability of iPSC-Based Neural In Vitro Assays for Neurotoxicity Testing

Screening for Environmental Toxins with a Human Brain in a Dish Model

Protocols & Application Notes

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Seeding and Maintenance of iN-Astrocyte Co-Cultures for MEA (Microelectrode Array) Applications

Application note cover

Long-term functional characterization of SynFire® iNs and astrocytes co-cultured on MaxTwo Multi-Well High-Density Microelectrode Arrays

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SynFire® iN Plating Protocol and Chemical Long-Term Potentiation on MaxWell Biosystems Multi-Well High-Density Microelectrode Array (HD-MEA) selected.

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