Unleashing Neuroscience's True Potential
The basis of NeuCyte’s technology is the proprietary methods for producing SynFire® cells. These highly functional human neural cells are made from induced pluripotent stem cells (iPSCs). Using exclusively licensed reprogramming technology from Stanford University, we can create large lots of homogenous populations of multiple neuronal subtypes.
SynFire induced neurons (iNs) exhibit the main characteristics of human primary neurons, such as expression of typical pan-neuronal markers and complex electrophysiology, including spontaneous and evoked action potentials and synchronized network activity.
TUJ-1/ GaABA/ Hoechst
TUJ-1/ GFAP/ Hoechst
SynFire iNs represent a versatile in vitro cell system for basic research and disease modeling, drug discovery and development. These cells are suitable for a variety of functional assays. For example, the effect of compounds on neuronal survival, axonal outgrowth, or dendritic arborization can be measured by standard assessment of viability, or image-based analysis of
labeled cells, respectively. When co-cultured with glial cells, effects on synapse formation and composition, transcriptional programs, and electrophysiology can be tested.
Based on SynFire technology, our human neural in vitro systems are uniquely suited for assessing relevant higher order elecotrophisiology readouts wich allow for a more reliable predictor of drug efficacy and potential neural safety/toxicology. NeuCyte's unique human neural platform allows for the evaluation of human specific neural phenotypes that are not identifiable in traditional models.