Wild-Type iPSC-Derived Human Astrocytes (iAstrocytes)

Wild-type human iPSC-derived astrocytes (iAstrocytes) provide a physiologically relevant model for studying neurodevelopment, neuroinflammation, and neuron-glia interactions in the central nervous system (CNS). As the most abundant glial cell type in the brain, astrocytes regulate neurotransmitter uptake, synapse formation and maintenance, cytokine signaling, and blood-brain barrier integrity.

Wild-type iAstrocytes display typical astrocytic morphology and express canonical markers including GFAP, ALDH1L1, and CD44, with transcriptomic profiles closely resembling those of primary human astrocytes. Cells are fully differentiated and assay-ready five days post-thaw, demonstrating high viability, low expression of non-astrocytic markers, and robust immune responsiveness, including IL-6 secretion upon stimulation.

Designed for seamless integration into 2D or 3D SynFire co-cultures and microelectrode array (MEA) systems, iAstrocytes support synchronous neuronal network activity and functional maturation. Each lot undergoes rigorous quality control to ensure consistent purity, performance, and reproducibility across experiments.

FORMAT: Frozen

CELL TYPE: iPSC-Derived Human Astrocytes

SPECIES: Human

CELL AND TISSUE SOURCE: iPSC

DONOR STATUS: Normal