Wild-Type iPSC-Derived GABAergic Neurons

Wild-type human iPSC-derived GABAergic neurons (iGs) provide a physiologically relevant and reproducible model for investigating inhibitory neurotransmission, neuronal network balance, and central nervous system (CNS) disorders associated with synaptic dysfunction. These inhibitory neurons form mature, functional networks in vitro and exhibit electrophysiological and pharmacological properties characteristic of native human GABAergic neurons.

In mono- or co-culture with iPSC-derived astrocytes or glutamatergic neurons, wild-type iGs display robust spontaneous activity, calcium signaling, and inhibitory responses modulated by GABA receptor antagonists such as bicuculline (BIC) and picrotoxin (PTX). Cells show high reproducibility across lots and are ideal for compound screening, disease modeling, and network dynamics studies.

Each lot is cryopreserved and assay-ready 28 days post-thaw, ensuring purity, sterility, and stable inhibitory network formation. Wild-type iGs integrate seamlessly into the SynFire platform for MEA, imaging, and high-throughput functional analysis.

FORMAT: Frozen

CELL TYPE: iPSC-Derived GABAergic Neurons

SPECIES: Human

CELL AND TISSUE SOURCE: iPSC

DONOR STATUS: Normal