Wild-Type iPSC-Derived Glutamatergic Neurons
Wild-type human iPSC-derived glutamatergic neurons (iNs) provide a physiologically relevant model for investigating excitatory neurotransmission, synaptic plasticity, and central nervous system (CNS) disorders. These excitatory neurons form mature, functional synaptic networks in vitro and exhibit electrophysiological properties characteristic of native human glutamatergic neurons.
When cultured independently or in co-culture with iPSC-derived astrocytes or GABAergic neurons, wild-type iNs display robust action potential firing, voltage-dependent Na⁺ and K⁺ currents, and spontaneous calcium transients. Cells demonstrate compound sensitivity to AMPA receptor antagonists such as CNQX, supporting applications in neurotoxicity testing, disease modeling, and CNS drug discovery.
Each lot is cryopreserved and assay-ready after 28 days in culture, with verified purity, sterility, and consistent network activity across batches. Wild-type iNs integrate seamlessly into the SynFire platform for high-content imaging, electrophysiological recording, and functional connectivity studies.
FORMAT: Frozen
CELL TYPE: iPSC-Derived Glutamatergic Neurons
SPECIES: Human
CELL AND TISSUE SOURCE: iPSC
DONOR STATUS: Normal
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